The Cyber-Physical Systems Virtual Organization (CPS-VO) was founded by NSF in 2010 to: (i)facilitate and foster interaction and exchanges among CPS PIs and their teams; (ii) enable sharing of artifacts and knowledge generated by the projects with the broader engineering and scientific communities; and (iii) facilitate and foster collaboration and information exchange between CPS researchers and industry. During the last five years, the CPS-VO has become the focal point of the CPS community in the US and it has played a significant role in catalyzing CPS research world-wide.